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Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Gene Name: | ubiquitin-conjugating enzyme E2L 3 |
Synonyms: | UBE2L3, E2-F1, L-UBC, UBCH7, UBCE7, Ubiquitin carrier protein L3, UbcM4, Ubiquitin-protein ligase L3 |
Target Sequences: | NM_003347 NP_003338.1 P68036 |
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