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UBE2I / UBC9

ubiquitin-conjugating enzyme E2I

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.

Gene Name:	ubiquitin-conjugating enzyme E2I
Synonyms:	UBE2I, C358B7.1, SUMO-conjugating enzyme UBC9, UBC9, SUMO-protein ligase, UBCE9, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-protein ligase I, p18, SUMO-1-protein ligase, Ubiquitin conjugating enzyme 9, Ubiquitin-protein ligase E2I
Target Sequences:	NM_003345 NP_003336.1 P63279

Publications (1)

The SUMOylation of matrix protein M1 modulates the assembly and morphogenesis of influenza A virus. Wu CY, Jeng KS, Lai MM. Journal of virology. 2011 85:6618-28. [PubMed:21507966] [PMC:PMC3126537] Related Antibodies: LS-C96463.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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