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UBCH10 / UBE2C

Ubiquitin-conjugating enzyme E2C

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Gene Name:	Ubiquitin-conjugating enzyme E2C
Synonyms:	UBE2C, DJ447F3.2, UBCH10, Ubiquitin-protein ligase C, Ubiquitin carrier protein E2-C, Ubiquitin carrier protein C
Target Sequences:	NM_007019 NP_008950.1 O00762

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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