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UBC6 / UBE2J2
ubiquitin-conjugating enzyme E2, J2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
| Gene Name: | ubiquitin-conjugating enzyme E2, J2 |
| Synonyms: | UBE2J2, NCUBE2, Ubc6p, Ubiquitin conjugating enzyme 6, NCUBE-2, Yeast UBC6 homolog, PRO2121, UBC6 |
| Target Sequences: | NM_194315 NP_919296.1 Q8N2K1 |
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