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UBASH3A / CLIP4

ubiquitin associated and SH3 domain containing A

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Gene Name:	ubiquitin associated and SH3 domain containing A
Synonyms:	UBASH3A, STS2, TULA-1, STS-2, T-cell ubiquitin ligand 1, TULA, Cbl-interacting protein 4
Target Sequences:	NM_018961 NP_061834.1 P57075

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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