U2AF2 / U2AF65

U2 small nuclear RNA auxiliary factor 2

Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

U2AF2 / U2AF65 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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U2AF2 / U2AF65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114719

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.3 kDa

Price:

100 µg/$710

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Human U2AF2 / U2AF65 Protein (Recombinant GST, N-terminus) (aa141-240) - LS-G61834

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human U2AF2 / U2AF65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78942

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.3 kDa

Price:

20 µg/$215

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