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U2AF1L4
U2 small nuclear RNA auxiliary factor 1-like 4
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site.
| Gene Name: | U2 small nuclear RNA auxiliary factor 1-like 4 |
| Synonyms: | U2AF1L4, U2AF1L3V1, U2AF1RS3, U2 auxiliary factor 26, U2AF1-like protein 3, U2af26, U2AF1-RS3, U2AF1L3 |
| Target Sequences: | NP_659424.2 |
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