Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
|Gene Name:||TYRO3 protein tyrosine kinase|
|Family/Subfamily:||Protein Kinase , Axl|
|Synonyms:||TYRO3, Brt, BYK, Dtk, Sky kinase, Sky, Tif, Tyrosine-protein kinase byk, Tyrosine-protein kinase SKY, Tyrosine-protein kinase DTK, TYRO3 protein tyrosine kinase, Tyrosine-protein kinase brt, RSE, Tyrosine-protein kinase RSE|
|Target Sequences:||NM_006293 NP_006284.2 Q06418|
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.