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May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Gene Name: | thioredoxin interacting protein |
Synonyms: | TXNIP, HHCPA78, THIF, VDUP1, Thioredoxin binding protein 2, Thioredoxin-binding protein 2, EST01027 |
Target Sequences: | NM_006472 NP_006463.3 Q9H3M7 |
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