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TUSC3

tumor suppressor candidate 3

TUSC3 is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: tumor suppressor candidate 3
Synonyms: TUSC3, D8S1992, M33, MRT7, N33, OST3A, Tumor suppressor candidate 3, Protein N33, MRT22
Target Sequences: NM_006765 NP_006756.2 Q13454

Publications (2)

1
Low levels of tumor suppressor candidate 3 predict poor prognosis of patients with hepatocellular carcinoma. Sheng XR, Xing SG, Wang RD, Chen K, Jia WD. OncoTargets and therapy. 2018 February;11:909-917. (Human) [Full Text Article] [PubMed:29503566] [PMC:PMC5825997] Related Antibodies: LS-B13274.
2
miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Jeon YJ, Kim T, Park D, Nuovo GJ, Rhee S, Joshi P, Lee BK, Jeong J, Suh SS, Grotzke JE, Kim SH, Song J, Sim H, Kim Y, Peng Y, Jeong Y, Garofalo M, Zanesi N, Kim J, Liang G, Nakano I, Cresswell P, Nana-Sinkam P, Cui R, Croce CM. Nature communications. 2018 November;9:5110. [Full Text Article] [PubMed:30504895] [PMC:PMC6269493] Related Antibodies: LS-C384735.

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
TUSC3 (6)
No (6)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
TUSC3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.5 kDa
100 µg/$494
TUSC3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
100 µg/$494
TUSC3 Protein - 12.5% SDS-PAGE of human TUSC3 stained with Coomassie Blue
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Wheat Germ Extract
GST
66 kDa
10 µg/$479; 25 µg/$670
TUSC3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TUSC3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.5 kDa
20 µg/$150
TUSC3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).