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Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.
Gene Name: | tubulin tyrosine ligase-like family, member 3 |
Synonyms: | TTLL3, Tubulin monoglycylase TTLL3, DKFZP434B103, HOTTL |
Target Sequences: | NM_015644 |
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