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Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Gene Name: | TELO2 interacting protein 1 |
Synonyms: | TTI1, KIAA0406, Protein SMG10, SMG10, TELO2 interacting protein 1, Smg-10, Tel two interacting protein 1 |
Target Sequences: | NM_014657 NP_055472.1 |
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