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TTC3
tetratricopeptide repeat domain 3
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
| Gene Name: | tetratricopeptide repeat domain 3 |
| Synonyms: | TTC3, DCRR1, RNF105, TPRD, TPRDI, TPR repeat protein 3, TPRDIII, TPR repeat protein D, Protein DCRR1, RING finger protein 105, TPRDII |
| Target Sequences: | NM_003316 NP_003307.3 P53804 |
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