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TSTA3 / GDP-L-Fucose Synthase

tissue specific transplantation antigen P35B

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.

Gene Name: tissue specific transplantation antigen P35B
Synonyms: TSTA3, 3-5 epimerase/4-reductase, FX, GDP-L-fucose synthase, SDR4E1, p35B, Protein FX
Target Sequences: NM_003313 NP_003304.1 Q13630

Publications (1)

1
Glycomic Profiling Highlights Increased Fucosylation in Pseudomyxoma Peritonei. Saarinen L, Nummela P, Leinonen H, Heiskanen A, Thiel A, Haglund C, Lepistö A, Satomaa T, Hautaniemi S, Ristimäki A. Molecular & cellular proteomics : MCP. 2018 November;17:2107-2118. [Full Text Article] [PubMed:30072579] [PMC:PMC6210226] Related Antibodies: LS-B9837.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).