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TSPAN12

tetraspanin 12

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Gene Name:	tetraspanin 12
Family/Subfamily:	Tetraspan , not assigned-Tetraspan
Synonyms:	TSPAN12, EVR5, NET-2, NET2, Tetraspan NET-2, Tetraspanin-12, TM4SF12, Tspan-12, Tetraspanin 12
Target Sequences:	NM_012338 NP_036470.1 O95859

Publications (1)

Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of ß-Catenin Signaling. Bucher F, Zhang D, Aguilar E, Sakimoto S, Diaz-Aguilar S, Rosenfeld M, Zha Z, Zhang H, Friedlander M, Yea K. Circulation. 2017 July;136:180-195. [Full Text Article] [PubMed:28356444] Related Antibodies: LS-B9720.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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