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TSG / TWSG1

twisted gastrulation BMP signaling modulator 1

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.

Gene Name: twisted gastrulation BMP signaling modulator 1
Synonyms: TWSG1, TSG
Target Sequences: NM_020648 NP_065699.1 Q9GZX9

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Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
TSG / TWSG1 (9)
No (9)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His (2)
Myc-DDK (Flag) (2)
Human (7)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (4)
Biologically active (1)
TSG / TWSG1 Protein - Recombinant Twisted Gastrulation Protein Homolog 1 By SDS-PAGE
Select
E. coli
His
25.8 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
TSG / TWSG1 Protein - 12.5% SDS-PAGE of human TWSG1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
50.05 kDa
10 µg/$479; 25 µg/$670
TSG / TWSG1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TSG / TWSG1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
24.8 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
100 µg/$721
TSG / TWSG1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
24.8 kDa
100 µg/$494
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
22.2 kDa
10 µg/$268; 50 µg/$349
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.2 kDa
10 µg/$297; 50 µg/$460
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.18kD
10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157
Viewing 1-9 of 9 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).