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TSC22D3 / GILZ
TSC22 domain family, member 3
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
| Gene Name: | TSC22 domain family, member 3 |
| Synonyms: | TSC22D3, DSIPI, DIP, DSIP-immunoreactive peptide, GILZ, TSC-22 related protein, Protein DIP, TSC22 domain family protein 3, HDIP, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22 domain family, member 3 |
| Target Sequences: | NM_004089 NP_004080.2 Q99576 |
Publications (2)
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