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20700 44th Avenue W
Lynnwood, WA 98036
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TSAP6 / STEAP3
STEAP family member 3, metalloreductase
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
| Gene Name: | STEAP family member 3, metalloreductase |
| Synonyms: | STEAP3, Dudulin-2, Dudlin 2, Dudlin-2, Dudulin 2, Metalloreductase STEAP3, HTSAP6, PHyde, Tumor suppressor pHyde, TSAP6, HpHyde, STMP3 |
| Target Sequences: | NM_018234 NP_060704.2 Q658P3 |
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