TRPM5

transient receptor potential cation channel, subfamily M, member 5

Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

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Proteins (2)

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Over-Expression Lysate (2)

Target

TRPM5 (2)

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Myc-DDK (Flag) (2)

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Human (1)

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293T Cells (1)

HEK 293 Cells (1)

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Human TRPM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91377

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

131.3 kDa

Price:

20 µg/$150

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TRPM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113864

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

131.3 kDa

Price:

100 µg/$494

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