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Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1.
Gene Name: | transient receptor potential cation channel, subfamily C, member 4 associated protein |
Synonyms: | TRPC4AP, C20orf188, DJ756N5.2, DKFZP727M231, Protein TAP1, TRUSS, Trpc4-associated protein, TRRP4AP, Protein TRUSS, Trp4-associated protein |
Target Sequences: | AF055022 CAB55953.1 Q8TEL6 |
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