TRIM5

tripartite motif containing 5

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5a variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5a acts as a natural barrier to cross-species retrovirus transmission (3). While a function has not yet been assigned to TRIM5g, it is known that expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. Furthermore, the TRIM5d isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner. The TRIM5d isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5d also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.

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Products

Proteins (15)

Type

Over-Expression Lysate (7)

Recombinant (8)

Target

TRIM5 (15)

Publications

No (15)

Tag

6His, N-terminus (3)

6His-B2M, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (11)

Mouse (1)

Source

293T Cells (4)

E. coli (6)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human TRIM5 Protein (Recombinant His-T7, N-terminus) (Ala2-Thr261) - LS-G133417

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

33.7kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108440

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

100 µg/$494

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TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108441

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.9 kDa

Price:

100 µg/$494

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Human TRIM5 Protein (Recombinant GST) (Full Length) - LS-G35906

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TRIM5 Protein (Recombinant 6His, N-terminus) (aa1-493) - LS-G56058

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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Human TRIM5 Protein (Recombinant 6His-B2M, N-terminus) (aa1-493) - LS-G56944

Source:

E. coli

Tag:

6His-B2M, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TRIM5 Protein (Recombinant GST, N-terminus) (aa309-418) - LS-G63431

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85908

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.2 kDa

Price:

20 µg/$150

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Human TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85907

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.2 kDa

Price:

20 µg/$215

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Human TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85909

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.9 kDa

Price:

20 µg/$150

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Human TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85910

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

20 µg/$150

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TRIM5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102105

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.2 kDa

Price:

100 µg/$710

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Human TRIM5 Protein (Recombinant 6His, N-terminus) (Met1-Gln248) - LS-G140434

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

30.8 kDa

Price:

10 µg/$344; 50 µg/$584

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Human TRIM5 Protein (Recombinant 6His, N-terminus) (Met1-Gln248) - LS-G39815

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

30.8kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Mouse TRIM5 Protein (Recombinant His, N-Terminal) (Ala2-Ser218) - LS-G132691

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.7kDa

Price:

10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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