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TRIM33 / TIF1-Gamma
tripartite motif containing 33
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
| Gene Name: | tripartite motif containing 33 |
| Family/Subfamily: | Tripartite Motif , TIF1 |
| Synonyms: | TRIM33, Ectodermin homolog, ECTO, RET-FUSED GENE 7, RFG7, TF1G, TIF1GAMMA, TIFGAMMA, TIF1-gamma, PTC7, RET-fused gene 7 protein, TIF1G, Tripartite motif-containing 33, KIAA1113, Protein Rfg7, Tripartite motif containing 33 |
| Target Sequences: | NM_015906 NP_056990.3 Q9UPN9 |
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