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TRIM29

tripartite motif containing 29

TRIM29 belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.

Gene Name: tripartite motif containing 29
Family/Subfamily: Tripartite Motif
Synonyms: TRIM29, ATDC, Tripartite motif containing 29, Tripartite motif-containing 29
Target Sequences: NM_012101 NP_036233.2 Q14134

Publications (3)

1
The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E. Molecular and cellular biology. 2010 30:3004-15. [PubMed:20368352] [PMC:PMC2876676] Related Antibodies: LS-C154244.
2
Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein. Yuan Z, Peng L, Radhakrishnan R, Seto E. The Journal of biological chemistry. 2010 285:39329-38. [PubMed:20947501] [PMC:PMC2998079] Related Antibodies: LS-C154244.
3
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Vinee Purohit , Lidong Wang , Huibin Yang, Jiufeng Li, Gina M Ney, Erica R Gumkowski, Akash J Vaidya, Annie Wang, Amit Bhardwaj, Ende Zhao, Igor Dolgalev, Andrea Zamperone, Ethan V Abel, Marina Pasca Di Magliano, Howard C Crawford, Daniel Diolaiti, Thales Y Papagiannakopoulos, Costas A Lyssiotis, Diane M Simeone. Genes & development. 2021 February;35:218-233. [Full Text Article] [PubMed:33446568] [PMC:PMC7849366]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).