Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 610/620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

TRIM21 / RO52

tripartite motif containing 21

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.

Gene Name: tripartite motif containing 21
Family/Subfamily: Tripartite Motif
Synonyms: TRIM21, 52 kDa Ro protein, RING finger protein 81, RO52, Ro(SS-A), SSA1, Tripartite motif-containing 21, RNF81, SSA, Sicca syndrome antigen A, SS-A, Tripartite motif containing 21
Target Sequences: NM_003141 NP_003132.2 P19474

☰ Filters
Antibodies (37)
Proteins (12)
ELISA Kits (4)
Custom (2)
Over-Expression Lysate (2)
Primary (37)
Recombinant (10)
Sandwich (2)
TRIM21 / RO52 (53)
Human (34)
Mouse (13)
Rat (9)
Bovine (1)
Chimpanzee (9)
Gibbon (6)
Guinea pig (3)
Monkey (4)
Pig (6)
IHC (10)
IHC-P (5)
WB (27)
ELISA (12)
ICC (2)
IF (5)
IP (2)
Peptide-ELISA (2)
SDS-PAGE (1)
rabbit (32)
mouse (2)
goat (1)
human (1)
sheep (1)
Product Group
IHCPlus (3)
IgG (31)
IgG1 (1)
IgG2a,k (1)
monoclonal mc (2)
polyclonal pc (35)
2C9 (1)
TS106 (1)
96-Well Strip Plate (4)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
Unconjugated (22)
C-Terminus (4)
aa1-470 (4)
aa144-193 (4)
aa51-100 (4)
aa1-475 (1)
aa12-262 (1)
aa195-293 (1)
aa250-300 (1)
aa254-475 (1)
aa425-475 (1)
aa463-475 (1)
No (53)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (2)
Serum (2)
Tissue Homogenates (1)
6His, N-terminus (3)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
His,N-terminus (1)
His-SUMO (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (3)
Human (8)
Mouse (2)
Rat (1)
293T Cells (1)
Baculovirus (1)
E. coli (5)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (2)
Low endotoxin level (1)
TRIM21 / RO52 Antibody - Anti-TRIM21 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
TRIM21 / RO52 Goat anti-Human Polyclonal (aa463-475) Antibody
Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Select
TRIM21 / RO52 Mouse anti-Human Monoclonal (aa195-293) (TS106) Antibody
Human
ICC
Unconjugated
100 µg/$896
Select
TRIM21 / RO52 Human anti-Human Polyclonal Antibody
Bovine, Human
ELISA
Unconjugated
2 ml/$467
TRIM21 / RO52 Protein
Select
Yeast
6His, N-terminus
56.17 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
Select
E. coli
6His, N-terminus
58.2 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TRIM21 / RO52 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (aa425-475) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
TRIM21 / RO52 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
TRIM21 / RO52 Protein
Select
E. coli
His-SUMO
70.14 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
TRIM21 / RO52 Protein - Recombinant Sjogren Syndrome Antigen A1 (SSA1) by SDS-PAGE
Select
E. coli
6His, N-terminus
26.4kDa
10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832
TRIM21 / RO52 Antibody - Immunohistochemistry of paraffin-embedded mouse heart using TRIM21 antibody at dilution of 1:100 (40x lens).
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
TRIM21 / RO52 Mouse anti-Human Monoclonal (2C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
TRIM21 / RO52 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Select
TRIM21 / RO52 Rabbit anti-Mouse Polyclonal (aa1-470) (HRP) Antibody
Mouse
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
TRIM21 / RO52 Antibody - Transfected 293T cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (aa51-100) Antibody
Human
WB
Unconjugated
100 µl/$397
TRIM21 / RO52 Antibody - Transfected 293T cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (aa51-100) (HRP) Antibody
Mouse, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$442
TRIM21 / RO52 Protein
Select
Baculovirus
His,N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TRIM21 consists of 494 amino acids and predicts a molecular mass of 56.5 kDa.
100 µg/$519
TRIM21 / RO52 Protein - Recombinant Sjogren Syndrome Antigen A1 (SSA1) by SDS-PAGE
Select
E. coli
His-T7, N-terminus
26.1kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (aa12-262) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
TRIM21 / RO52 Antibody - Immunofluorescence analysis of U2OS cells.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TRIM21 / RO52 Antibody - Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
WB
Unconjugated
100 µl/$424
TRIM21 / RO52 Antibody - Transfected 293T cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
TRIM21 / RO52 Antibody - IHC of paraffin-embedded DLD-1 xenograft using SSA1 antibody at 1:500 dilution.
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (aa254-475) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
TRIM21 / RO52 Antibody - Immunohistochemistry image of paraffin-embedded human lung tissue at a dilution of 1:100
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
TRIM21 / RO52 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 53 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).