TRIM11

tripartite motif containing 11

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

TRIM11 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human TRIM11 Protein (Recombinant GST, N-terminus) (aa132-230) - LS-G63272

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TRIM11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87398

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

20 µg/$150

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Human TRIM11 Protein (Recombinant His-SUMO) (aa267-468) - LS-G21888

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

38.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TRIM11 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70545

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

20 µg/$1,107

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TRIM11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102312

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

100 µg/$494

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