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TRIAP1

TP53 Regulated Inhibitor Of Apoptosis 1

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.

Gene Name: TP53 Regulated Inhibitor Of Apoptosis 1
Synonyms: TRIAP1, 15E1.1, HSPC132, MDM35, WF-1, p53CSV, Protein 15E1.1
Target Sequences: NM_016399 NP_057483.1

Publications (1)

1
MicroRNA-18a inhibits ovarian cancer growth via directly targeting TRIAP1 and IPMK. Liu P, Qi X, Bian C, Yang F, Lin X, Zhou S, Xie C, Zhao X, Yi T. Oncology letters. 2017 13:4039-4046. (IHC; Human) [Full Text Article] [PubMed:28588697] [PMC:PMC5452870] Related Antibodies: LS-B14596.

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Proteins (5)
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TRIAP1 (5)
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GST, N-terminus (1)
His (1)
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HEK 293 Cells (2)
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TRIAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
8.6 kDa
100 µg/$494
TRIAP1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
TRIAP1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TRIAP1 Protein - Purified recombinant protein TRIAP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
8.6 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
8.6 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).