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TRB3 / TRIB3

tribbles pseudokinase 3

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Gene Name: tribbles pseudokinase 3
Synonyms: TRIB3, C20orf97, NIPK, SINK, TRB-3, TRB3, DJ1103G7.3, SKIP3, Tribbles homolog 3
Target Sequences: NM_021158 NP_066981.2 Q96RU7

Publications (1)

1
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. A Blumental-Perry, R Jobava, I Bederman, A J Degar, H Kenche, B J Guan, K Pandit, N A Perry, N D Molyneaux, J Wu, E Prendergas, Z-W Ye, J Zhang, C E Nelson, F Ahangari, D Krokowski, S H Guttentag, P A Linden, D M Townsend, A Miron, M-J Kang, N Kaminski, Y Perry, M Hatzoglou. Communications biology. 2020 October;3:626. [Full Text Article] [PubMed:33127975] [PMC:PMC7603330] Related Antibodies: LS-C164592.

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Antibodies (67)
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TRB3 / TRIB3 (78)
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rabbit (55)
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TRB3 / TRIB3 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TRB3 / TRIB3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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TRB3 / TRIB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
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TRB3 / TRIB3 Rabbit anti-Mouse Polyclonal (aa305-334) Antibody
Mouse
WB
Unconjugated
400 µl/$393
TRB3 / TRIB3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
TRB3 / TRIB3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
TRB3 / TRIB3 Protein
Select
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
TRB3 / TRIB3 Antibody - Anti-TRIB3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
TRB3 / TRIB3 Antibody - Anti-TRIB3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
TRB3 / TRIB3 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3G4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3C6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI3C6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Antibody - Immunohistochemical staining of human tissue using anti-TRB3 (human), pAb at 1:2000 dilution. . 1: Immunoperoxidase staining (cytoplasmic) of formalin-fixed, paraffin-embedded human salivary glands (200x, brown color).
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TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa112-125) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$323
TRB3 / TRIB3 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3F3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI3F3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3F6) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI3F6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI1F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Antibody - Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI1F6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Viewing 1-25 of 78 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).