Translokin / CEP57

centrosomal protein 57kDa

Translokin / CEP57 is a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

Translokin / CEP57 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human Translokin / CEP57 Protein (Recombinant GST) (Full Length) - LS-G31765

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.63 kDa

Price:

10 µg/$479; 25 µg/$670

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Human Translokin / CEP57 Protein (Recombinant GST, N-terminus) (aa19-128) - LS-G61225

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human Translokin / CEP57 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77017

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

20 µg/$150

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Translokin / CEP57 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101245

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

100 µg/$494

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Human Translokin / CEP57 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144809

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

84.9 kDa

Price:

50 µg/$419

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