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TRAFD1 / FLN29

TRAF-type zinc finger domain containing 1

Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.

Gene Name:	TRAF-type zinc finger domain containing 1
Synonyms:	TRAFD1, FLN29, Protein FLN29, FLN29 gene product
Target Sequences:	NM_006700 NP_006691.1 O14545

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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