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TRAF6

TNF receptor-associated factor 6, E3 ubiquitin protein ligase

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Gene Name: TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Synonyms: TRAF6, RING finger protein 85, MGC:3310, RNF85
Target Sequences: NM_004620 NP_004611.1 Q9Y4K3

Publications (1)

1
miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6. Jiang S, Hu Y, Deng S, Deng J, Yu X, Huang G, Kawai T, Han X. Biochem Biophys Acta Molecular Basis of Disease. 2018 March;1864:925-933. [Full Text Article] [PubMed:29288795] [PMC:PMC5803357]

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Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
TRAF6 (10)
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His-T7 (2)
Myc-DDK (Flag) (5)
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293T Cells (2)
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HEK 293 Cells (3)
Wheat Germ Extract (2)
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E. coli
His-SUMO
75.6 kD
100 µg/$420; 1 mg/$1,355; 20 µg/$323
TRAF6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TRAF6 Protein - Purified recombinant protein TRAF6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
59.4 kDa
20 µg/$1,107
TRAF6 Protein - 12.5% SDS-PAGE of human TRAF6 stained with Coomassie Blue
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Wheat Germ Extract
GST
86 kDa
2 µg/$439
TRAF6 Protein - Recombinant  TNF Receptor Associated Factor 6 By SDS-PAGE
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E. coli
His-T7
29.5 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
TRAF6 Protein - Recombinant TNF Receptor Associated Factor 6 By SDS-PAGE
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E. coli
His-T7
35.2 kDa
10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
TRAF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.4 kDa
100 µg/$494
TRAF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.4 kDa
100 µg/$494
TRAF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.4 kDa
20 µg/$150
TRAF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.4 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).