TRAF6

TNF receptor-associated factor 6, E3 ubiquitin protein ligase

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

☰ Filters

Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

TRAF6 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His-SUMO (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Mouse (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

Human TRAF6 Protein (Recombinant His-SUMO) (Full Length) - LS-G21289

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

75.6 kD

Price:

100 µg/$420; 1 mg/$1,355; 20 µg/$323

Select

Human TRAF6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81827

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.4 kDa

Price:

20 µg/$150

Select

Human TRAF6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81828

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.4 kDa

Price:

20 µg/$150

Select

TRAF6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102325

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.4 kDa

Price:

100 µg/$494

Select

Human TRAF6 Protein (Recombinant His-T7) (aa153-423) - LS-G15790

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.2 kDa

Price:

10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988

Select

Mouse TRAF6 Protein (Recombinant His-T7) (aa254-475) - LS-G25780

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.5 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

Select

Human TRAF6 Protein (Recombinant GST, N-terminus) (aa413-522) - LS-G60415

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human TRAF6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68279

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.4 kDa

Price:

20 µg/$1,107

Select

TRAF6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100347

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.4 kDa

Price:

100 µg/$494

Select

Human TRAF6 Protein (Recombinant GST) (Full Length) - LS-G30771

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86 kDa

Price:

2 µg/$439

Viewing 1-10 of 10 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.