TRAF2

TNF receptor-associated factor 2

TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

TRAF2 (5)

Publications

No (5)

Tag

GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TRAF2 Protein (Recombinant GST) (Full Length) - LS-G30769

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.85 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse TRAF2 Protein (Recombinant His-T7) (aa238-491) - LS-G25781

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.4 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human TRAF2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68097

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.7 kDa

Price:

20 µg/$1,107

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Human TRAF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81447

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.7 kDa

Price:

20 µg/$150

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TRAF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101727

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.7 kDa

Price:

100 µg/$494

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