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Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Gene Name: | TraB domain containing 2A |
Synonyms: | TRABD2A, C2orf89, TIKI1, TraB domain containing 2A, UPF0632 protein C2orf89 |
Target Sequences: | NM_001080824 NP_001074293.1 Q86V40 |
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