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TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
TPIP (TPTE and PTEN homologous inositol lipid phosphatase), a novel phosphatase, has been suggested to affect the regulation of phosphoinositide signalling on the endoplasmic reticulum, and might also represent a tumor suppressor and functional homologue of PTEN in some tissues. Two isoforms of TPIP have been documented and they appear to be functionally distinct. TPIP alpha displays similar phosphoinositide 3-phosphatase activity compared with PTEN and appears to be localized on the endoplasmic reticulum. This is unusual as most signalling-lipid-metabolizing enzymes are not integral membrane proteins. TPIP beta lacks detectable phosphatase activity and is cytosolic.
| Gene Name: | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
| Family/Subfamily: | Non-protein Phosphatase , not assigned-Non-protein Phosphatase |
| Synonyms: | TPTE2, Lipid phosphatase TPIP, TPIP lipid phosphatase, TPIP |
| Target Sequences: | NM_130785 |
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