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TPSG1 / Tryptase Gamma 1

tryptase gamma 1

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Gene Name: tryptase gamma 1
Family/Subfamily: Protease , Serine S1
Synonyms: TPSG1, Mast cell protease II, Mast cell tryptase, Pituitary tryptase, Skin tryptase, Lung tryptase, TrpA, Tryptase gamma I, Transmembrane tryptase, Tryptase gamma, Tryptase gamma 1, PRSS31, TMT, Gamma I, Gamma II, Serine protease 31, Tryptase gamma II
Target Sequences: NM_012467 NP_036599.3 Q9NRR2

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
TPSG1 / Tryptase Gamma 1 (4)
No (4)
His (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
TPSG1 / Tryptase Gamma 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.76 kDa
20 µg/$150
TPSG1 / Tryptase Gamma 1 Protein - Purified recombinant protein TPSG1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32 kDa
20 µg/$1,107
TPSG1 / Tryptase Gamma 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.76 kDa
100 µg/$494
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E. coli
His
17.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).