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Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t6A activity of the complex. TPRKB is not required for tRNA modification.
Gene Name: | TP53RK binding protein |
Synonyms: | TPRKB, CGI-121, TP53RK binding protein, PRPK-binding protein, TP53RK-binding protein |
Target Sequences: | NM_016058 NP_057142.1 Q9Y3C4 |
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