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Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Gene Name: | tropomyosin 2 (beta) |
Synonyms: | TPM2, AMCD1, Beta-tropomyosin, DA1, DA2B, NEM4, Tropomyosin-2, Tropomyosin 2 (beta), TMSB, Tropomyosin beta chain |
Target Sequences: | NM_003289 NP_003280.2 P07951 |
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