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TPI1 / TPI encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
Gene Name: | triosephosphate isomerase 1 |
Synonyms: | TPI1, Triose-phosphate isomerase, Triosephosphate isomerase, TPI, Triosephosphate isomerase 1, TIM |
Target Sequences: | NM_000365 NP_000356.1 P60174 |
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