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TPH1 / Tryptophan Hydroxylase

tryptophan hydroxylase 1

TPH1 / TPH encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

Gene Name: tryptophan hydroxylase 1
Family/Subfamily: Monooxygenase
Synonyms: TPH1, L-tryptophan hydroxylase, TRPH, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPRH, Tryptophan hydroxylase 1, TPH
Target Sequences: NM_004179 NP_004170.1 P17752

Publications (1)

1
Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer. Hallett RM, Girgis-Gabardo A, Gwynne WD, Giacomelli AO, Bisson JN, Jensen JE, Dvorkin-Gheva A, Hassell JA. Oncotarget. 2016 7:53137-53152. (WB; Human) [Full Text Article] [PubMed:27447971] [PMC:PMC5288174] Related Antibodies: LS-C117936.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
TPH1 / Tryptophan Hydroxylase (7)
No (7)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
TPH1 / Tryptophan Hydroxylase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TPH1 / Tryptophan Hydroxylase Protein - 12.5% SDS-PAGE of human TPH1 stained with Coomassie Blue
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Wheat Germ Extract
GST
77.4 kDa
10 µg/$479; 25 µg/$670
TPH1 / Tryptophan Hydroxylase Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
TPH1 / Tryptophan Hydroxylase Protein - Purified recombinant protein TPH1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
50.8 kDa
20 µg/$1,107
TPH1 / Tryptophan Hydroxylase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
50.8 kDa
20 µg/$215
TPH1 / Tryptophan Hydroxylase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50.8 kDa
100 µg/$710
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E. coli
His
52.7 kDa
50 µg/$843
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).