TOP2B / Topoisomerase II Beta

topoisomerase (DNA) II beta 180kDa

TOP2B / Topoisomerase II Beta is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.

☰ Filters

Products

Proteins (2)

Type

Recombinant (2)

Target

TOP2B / Topoisomerase II Beta (2)

Publications

No (2)

Tag

GST, N-terminus (1)

His-T7 (1)

Species

Human (1)

Mouse (1)

Source

E. coli (1)

Wheat Germ Extract (1)

Select

Mouse TOP2B / Topoisomerase II Beta Protein (Recombinant His-T7) (aa446-655) - LS-G15370

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Human TOP2B / Topoisomerase II Beta Protein (Recombinant GST, N-terminus) (aa1411-1523) - LS-G60401

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Viewing 1-2 of 2 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.