TOP2A / Topoisomerase II Alpha

topoisomerase (DNA) II alpha 170kDa

TOP2A / Topoisomerase II Alpha is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

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Products

ELISA Kits (10)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (4)

Sandwich (2)

Target

TOP2A / Topoisomerase II Alpha (10)

Reactivity

Human (6)

Mouse (2)

Rat (2)

Chicken (1)

Pig (1)

Format

96-Well Microplate (4)

96-Well Strip Plate (6)

Publications

No (9)

Yes (1)

Sample Type

Adherent Cell Cultures (4)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Human TOP2A / Topoisomerase II Alpha (Sandwich ELISA) ELISA Kit - LS-F12830

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human Phospho-TOP2A / Topoisomerase II Alpha (Ser1106) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1412

(4.0) Rating

(1) Publication(s)

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human TOP2A / Topoisomerase II Alpha (Sandwich ELISA) ELISA Kit - LS-F33615

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Pig TOP2A / Topoisomerase II Alpha (Custom ELISA) ELISA Kit - LS-F20156

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat TOP2A / Topoisomerase II Alpha (Custom ELISA) ELISA Kit - LS-F20157

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Chicken TOP2A / Topoisomerase II Alpha (Custom ELISA) ELISA Kit - LS-F20158

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse TOP2A / Topoisomerase II Alpha (Custom ELISA) ELISA Kit - LS-F20159

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human TOP2A / Topoisomerase II Alpha (Cell-Based ELISA) ELISA Kit - LS-F2360

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human Phospho-TOP2A / Topoisomerase II Alpha (Thr1343) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1709

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-TOP2A / Topoisomerase II Alpha (Ser1525) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1747

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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