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Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
Gene Name: | tonsoku-like, DNA repair protein |
Synonyms: | TONSL, I-kappa-B-related protein, IkappaBR, IKBR, NFKBIL2, Tonsoku-like protein |
Target Sequences: | NM_013432 NP_038460.4 Q96HA7 |
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