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TNNI3 / Cardiac Troponin I

troponin I type 3 (cardiac)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Gene Name: troponin I type 3 (cardiac)
Synonyms: TNNI3, CTnI, CMD1FF, CMD2A, RCM1, Troponin I, cardiac, Troponin I, cardiac muscle, Troponin I type 3 (cardiac), Cardiac troponin I, CMH7
Target Sequences: NM_000363 NP_000354.4 P19429

Publications (4)

1
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
2
MR-guided pulsed focused ultrasound improves mesenchymal stromal cell homing to the myocardium. Kee W Jang, Tsang-Wei Tu, Robert B Rosenblatt, Scott R Burks, Joseph A Frank. Journal of cellular and molecular medicine. 2020 October; [Full Text Article] [PubMed:33067927] [PMC:PMC7701528]
3
Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction. Xiao-Mei Zeng, De-Hong Liu, Yong Han, Zhi-Qiang Huang, Ji-Wen Zhang, Qun Huang. American journal of translational research. 2020 April;12:901-911. [PubMed:32269722] [PMC:PMC7137057]
4
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy10<sup> Department of Molecular Cardiology, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands12<sup> Department of Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden14<sup> Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. p.van.der.meer. Niels Grote Beverborg #, Daniela Später # , Ralph Knöll # , Alejandro Hidalgo , Steve T Yeh, Zaher Elbeck, Herman H W Silljé, Tim R Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér , Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F Hoes, Cornelis J Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R Chien , Kenny M Hansson, Adam E Mullick, Rudolf A de Boer, Peter van der Meer. Nature communications. 2021 Aug;12:5180. [Full Text Article] [PubMed:34462437] [PMC:PMC8405807]
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TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$772
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$669
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$563
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$859
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$917
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$999
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Microplate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$563
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$809
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$653
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$809
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$744
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
3.125 - 200 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$776
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$537
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$861
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$887
TNNI3 / Cardiac Troponin I ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$653
TNNI3 / Cardiac Troponin I ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$653
TNNI3 / Cardiac Troponin I ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$653
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
TNNI3 / Cardiac Troponin I ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$571
TNNI3 / Cardiac Troponin I ELISA Kit
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Development Kit
Antibody Pair and Standard
Pig
62.4 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,352; 1000 Wells/$2,029
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$735
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).