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TNNI3 / Cardiac Troponin I

troponin I type 3 (cardiac)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Gene Name: troponin I type 3 (cardiac)
Synonyms: TNNI3, CTnI, CMD1FF, CMD2A, RCM1, Troponin I, cardiac, Troponin I, cardiac muscle, Troponin I type 3 (cardiac), Cardiac troponin I, CMH7
Target Sequences: NM_000363 NP_000354.4 P19429

Publications (5)

1
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
2
MR-guided pulsed focused ultrasound improves mesenchymal stromal cell homing to the myocardium. Kee W Jang, Tsang-Wei Tu, Robert B Rosenblatt, Scott R Burks, Joseph A Frank. Journal of cellular and molecular medicine. 2020 October; [Full Text Article] [PubMed:33067927] [PMC:PMC7701528]
3
Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction. Xiao-Mei Zeng, De-Hong Liu, Yong Han, Zhi-Qiang Huang, Ji-Wen Zhang, Qun Huang. American journal of translational research. 2020 April;12:901-911. [PubMed:32269722] [PMC:PMC7137057]
4
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy10<sup> Department of Molecular Cardiology, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands12<sup> Department of Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden14<sup> Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. p.van.der.meer. Niels Grote Beverborg #, Daniela Später # , Ralph Knöll # , Alejandro Hidalgo , Steve T Yeh, Zaher Elbeck, Herman H W Silljé, Tim R Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér , Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F Hoes, Cornelis J Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R Chien , Kenny M Hansson, Adam E Mullick, Rudolf A de Boer, Peter van der Meer. Nature communications. 2021 Aug;12:5180. [Full Text Article] [PubMed:34462437] [PMC:PMC8405807]
5
The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation. Guanghui Zheng, Fenglian He, Jing Xu, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L Bradley, Mary Ann Peberdy, Joseph P Ornato, Longyuan Jiang, Stefano Toldo, Tong Wang , Wanchun Tang. Cardiovascular drugs and therapy. 2022 January; [Full Text Article] [PubMed:34973094]
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TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TNNI3 / Cardiac Troponin I Mouse anti-Bovine Monoclonal Antibody
Frog, Chicken, Bovine, Rabbit, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$575
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TNNI3 / Cardiac Troponin I Mouse anti-Bovine Monoclonal (APC) Antibody
Frog, Chicken, Bovine, Rabbit, Mouse, Human
ELISA, IHC, WB
APC Conjugated
100 µl/$979
TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Cancer
TNNI3 / Cardiac Troponin I Goat anti-Human Polyclonal (aa27-40) Antibody
Human
ELISA, IHC-P
Unconjugated
0.25 mg/$565
TNNI3 / Cardiac Troponin I Antibody - TNNI3 / Cardiac Troponin I antibody immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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TNNI3 / Cardiac Troponin I Goat anti-Human Polyclonal (aa117-127) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
1 mg/$1,139
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,094
TNNI3 / Cardiac Troponin I Antibody - Western Blot Positive WB detected in:Rat heart tissue,Rat liver tissue All Lanes:Tnni3 antibody at 2.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 25 KDa Observed band size: 25 KDa
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TNNI3 / Cardiac Troponin I Rabbit anti-Mouse Polyclonal (aa2-211) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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TNNI3 / Cardiac Troponin I Chicken anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
1 mg/$469
TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (1E7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (aa190-196) (MF4) Antibody
Human
IHC, IP, WB
Unconjugated
0.2 mg/$459; 0.5 mg/$555
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal Antibody
Fish, Pig, Rat, Rabbit, Mouse, Goat, Dog, Bovine, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$316; 100 µg/$386
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (M18) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
1 mg/$811
TNNI3 / Cardiac Troponin I Antibody - Western blot of 35 ug of cell extracts from human (HeLa) cells using anti-TNNI3 antibody.
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (OTI4E5) Antibody
Dog, Human, Monkey
IF, WB
Unconjugated
100 µl/$434
TNNI3 / Cardiac Troponin I Antibody - Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using TNNI3 (Phospho-Ser22+Ser23) Antibody. The picture on the right is blocked with the phospho peptide.
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TNNI3 / Cardiac Troponin I Rabbit anti-Mouse Polyclonal (pSer22/Ser23) Antibody
Mouse, Rat
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,135
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,135
TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI3 / Cardiac Troponin I Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TNNI3 / Cardiac Troponin I Antibody - Immunohistochemistry analysis of paraffin-embedded human heart, using TNNI3 (Phospho-Ser43) Antibody. The picture on the right is blocked with the phospho peptide.
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TNNI3 / Cardiac Troponin I Rabbit anti-Human Polyclonal (pSer43) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TNNI3 / Cardiac Troponin I Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (aa23-29) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$485
TNNI3 / Cardiac Troponin I Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (aa41-49) Antibody
Human
ELISA, IHC-P, LateralFlow, SwELISA, WB
Unconjugated
0.5 mg/$485
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (aa169-184) (267) Antibody
Human
IHC, IP, WB
Unconjugated
0.2 mg/$459; 0.5 mg/$555
TNNI3 / Cardiac Troponin I Antibody - Western blot of Troponin I-C antibody
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TNNI3 / Cardiac Troponin I Rabbit anti-Human Polyclonal (30-110 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TNNI3 / Cardiac Troponin I Antibody - Immunohistochemical analysis of cTnI (pS43) staining in human heart formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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TNNI3 / Cardiac Troponin I Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
IHC, IP, WB
Biotin Conjugated
100 µl/$1,135
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
IHC, IP, WB
Biotin Conjugated
100 µl/$1,135
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).