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TNNI3 / Cardiac Troponin I

troponin I type 3 (cardiac)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Gene Name: troponin I type 3 (cardiac)
Synonyms: TNNI3, CTnI, CMD1FF, CMD2A, RCM1, Troponin I, cardiac, Troponin I, cardiac muscle, Troponin I type 3 (cardiac), Cardiac troponin I, CMH7
Target Sequences: NM_000363 NP_000354.4 P19429

Publications (5)

1
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
2
MR-guided pulsed focused ultrasound improves mesenchymal stromal cell homing to the myocardium. Kee W Jang, Tsang-Wei Tu, Robert B Rosenblatt, Scott R Burks, Joseph A Frank. Journal of cellular and molecular medicine. 2020 October; [Full Text Article] [PubMed:33067927] [PMC:PMC7701528]
3
Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction. Xiao-Mei Zeng, De-Hong Liu, Yong Han, Zhi-Qiang Huang, Ji-Wen Zhang, Qun Huang. American journal of translational research. 2020 April;12:901-911. [PubMed:32269722] [PMC:PMC7137057]
4
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy10<sup> Department of Molecular Cardiology, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands12<sup> Department of Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden14<sup> Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. p.van.der.meer. Niels Grote Beverborg #, Daniela Später # , Ralph Knöll # , Alejandro Hidalgo , Steve T Yeh, Zaher Elbeck, Herman H W Silljé, Tim R Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér , Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F Hoes, Cornelis J Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R Chien , Kenny M Hansson, Adam E Mullick, Rudolf A de Boer, Peter van der Meer. Nature communications. 2021 Aug;12:5180. [Full Text Article] [PubMed:34462437] [PMC:PMC8405807]
5
The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation. Guanghui Zheng, Fenglian He, Jing Xu, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L Bradley, Mary Ann Peberdy, Joseph P Ornato, Longyuan Jiang, Stefano Toldo, Tong Wang , Wanchun Tang. Cardiovascular drugs and therapy. 2022 January; [Full Text Article] [PubMed:34973094]
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TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TNNI3 / Cardiac Troponin I Mouse anti-Bovine Monoclonal Antibody
Frog, Chicken, Bovine, Rabbit, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$575
TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TNNI3 / Cardiac Troponin I Goat anti-Human Polyclonal (aa27-40) Antibody
Human
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TNNI3 / Cardiac Troponin I Antibody - TNNI3 / Cardiac Troponin I antibody immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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TNNI3 / Cardiac Troponin I Goat anti-Human Polyclonal (aa117-127) Antibody
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100 µg/$503
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
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1 mg/$1,139
TNNI3 / Cardiac Troponin I ELISA Kit
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96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
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1 Plate/$851
TNNI3 / Cardiac Troponin I ELISA Kit
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Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$587
TNNI3 / Cardiac Troponin I ELISA Kit
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96-Well Microplate
Mouse
7.81 - 500 pg/ml
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1 Plate/$626
TNNI3 / Cardiac Troponin I ELISA Kit
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15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$1,100
TNNI3 / Cardiac Troponin I ELISA Kit
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96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$626
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$685
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
TNNI3 / Cardiac Troponin I ELISA Kit
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96-Well Strip Plate
Pig
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$779
TNNI3 / Cardiac Troponin I ELISA Kit
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96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
TNNI3 / Cardiac Troponin I Protein
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E. coli
His, N-Terminal
25.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$585
TNNI3 / Cardiac Troponin I ELISA Kit
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96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
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E. coli
6His, N-terminus
26 kDa
1 mg/$2,029; 10 µg/$253; 50 µg/$308
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,094
TNNI3 / Cardiac Troponin I Antibody - Western Blot Positive WB detected in:Rat heart tissue,Rat liver tissue All Lanes:Tnni3 antibody at 2.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 25 KDa Observed band size: 25 KDa
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TNNI3 / Cardiac Troponin I Rabbit anti-Mouse Polyclonal (aa2-211) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
TNNI3 / Cardiac Troponin I ELISA Kit
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Sandwich
96-Well Microplate
Human
0.38 - 625 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
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TNNI3 / Cardiac Troponin I Chicken anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
1 mg/$469
TNNI3 / Cardiac Troponin I Protein - Recombinant Troponin I Type 3, Cardiac By SDS-PAGE
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E. coli
His, N-Terminal
25.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
TNNI3 / Cardiac Troponin I Antibody - Anti-TNNI3 / CTnI antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (1E7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal (aa190-196) (MF4) Antibody
Human
IHC, IP, WB
Unconjugated
0.2 mg/$459; 0.5 mg/$555
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TNNI3 / Cardiac Troponin I Mouse anti-Human Monoclonal Antibody
Fish, Pig, Rat, Rabbit, Mouse, Goat, Dog, Bovine, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$316; 100 µg/$386
Viewing 1-25 of 377 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).