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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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TNFSF14 / LIGHT
tumor necrosis factor (ligand) superfamily, member 14
TNFSF14 / LIGHT is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 14 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF14, CD258 antigen, CD258, Delta transmembrane LIGHT, Herpesvirus entry mediator A, HVEM-L, TR2, HVEML, LIGHT, LTg |
| Target Sequences: | NM_003807 NP_003798.2 O43557 |
Publications (1)
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