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TNFSF13 / APRIL

tumor necrosis factor (ligand) superfamily, member 13

TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Gene Name: tumor necrosis factor (ligand) superfamily, member 13
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF13, APRIL, CD256, CD256 antigen, TALL-2, TALL2, ZTNF2, TNF-related death ligand 1, TRDL-1, UNQ383/PRO715
Target Sequences: NM_003808 NP_003799.1 O75888

Publications (3)

1
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia. Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B. The Journal of clinical investigation. 2018 August;128:3535-3545. [Full Text Article] [PubMed:29771684] [PMC:PMC6063483]
2
Soluble a-proliferation-inducing ligand (sAPRIL), a novel serum biomarker predicting the recurrence and metastasis of pancreatic adenocarcinoma after surgery. Han L, Zhang W, Song F, Guo Y, Guo K, Zhou W. Molecular medicine reports. 2014 October;10:1978-1984. [Full Text Article] [PubMed:25110120]
3
Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas. Guadagnoli M, Kimberley FC, Phan U, Cameron K, Vink PM, Rodermond H, Eldering E, Kater AP, van Eenennaam H, Medema JP. Blood. 2011 Jun;117:6856-65. [Full Text Article] [PubMed:21543761] Related Antibodies: LS-C18659, LS-C18687, LS-C18658.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).