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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNFSF10 / TRAIL

tumor necrosis factor (ligand) superfamily, member 10

TNFSF10 / TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: tumor necrosis factor (ligand) superfamily, member 10
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF10, Apo-2L, APO2L, Apo-2 ligand, CD253, CD253 antigen, TRAIL, Protein TRAIL, TL2
Target Sequences: NM_003810 NP_003801.1 P50591

Publications (1)

1
IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Herzer K, Hofmann TG, Teufel A, Schimanski CC, Moehler M, Kanzler S, Schulze-Bergkamen H, Galle PR. Cancer research. 2009 69:855-62. [PubMed:19141642]

Viewing 1-25 of 151 items
TNFSF10 / TRAIL Antibody - Anti-TNFSF10 / TRAIL antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal to Human TNFSF10 / TRAIL
Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µl   $425.00
TNFSF10 / TRAIL Antibody - Anti-TRAIL antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
TNFSF10 / TRAIL Antibody - Anti-TNFSF10 / TRAIL antibody IHC of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $425.00
TNFSF10 / TRAIL Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $425.00
TNFSF10 / TRAIL Antibody - Anti-Human sTRAIL/Apo2L Western Blot Unreduced
Select
Mouse Monoclonal (IgG1) to Human TNFSF10 / TRAIL
Human
ELISA, WB
Unconjugated
500µg   $255.00
TNFSF10 / TRAIL Antibody - Staining of mouse TRAIL-transfected cells with 0.5 ug of Purified Rat IgG2a isotype control (open histogram) or 0.25 ug of Purified anti-mouse TRAIL (N2B2) (colored histogram) followed by PE Anti-Rat IgG (LS-C106534). Total viable cells were used for analysis.
Select
Rat Monoclonal [clone N2B2] (IgG2a,k) to Mouse TNFSF10 / TRAIL
Mouse
Flo
Unconjugated
50µg   $245.00; 100µg   $305.00; 500µg   0.5mg/ml   $385.00
Select
Mouse Monoclonal (IgG1,k) to Human TNFSF10 / TRAIL
Human
ELISA
Unconjugated
500µg   $395.00
TNFSF10 / TRAIL Antibody - Western blot of recombinant TNFSF10 / TRAIL.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal (IgG) to Human TNFSF10 / TRAIL
Human
WB
Unconjugated
20µl   1mg/ml   $195.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $275.00; 1ml   1mg/ml   $455.00
Select
Mouse Monoclonal [clone 366G/76/3] (IgG1) to Human TNFSF10 / TRAIL
Human
Flo, WB
Unconjugated
100µg   $815.00; 500µg   $950.00
TNFSF10 / TRAIL Antibody - Immunohistochemistry of paraffin-embedded human colon carcinoma tissue.
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
Select
Mouse Monoclonal (IgG2b) to Human TNFSF10 / TRAIL
Human
ELISA, Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100µg   1mg/ml   $415.00
Select
Mouse Monoclonal (IgG2b) to Human TNFSF10 / TRAIL
Human
ELISA, Flo, IP
Unconjugated
100µg   1mg/ml   $375.00
Select
Mouse Monoclonal [clone 2E5] (IgG1) to Human TNFSF10 / TRAIL
Human
Flo, WB
Unconjugated, Low Endotoxin
0.5mg   1mg/ml   $590.00
Select
Mouse Monoclonal [clone RIK-2] (IgG1) to Human TNFSF10 / TRAIL
Human
Flo
Unconjugated
100µg   0.5mg/ml   $275.00
TNFSF10 / TRAIL Antibody - Western blot of total cell lysate from Jurkat cells with antibody.
Select
Mouse Monoclonal [clone 55B709.3] (IgG) to Human TNFSF10 / TRAIL
Human
WB
Unconjugated
100µg   200µl   0.5mg/ml   $335.00
TNFSF10 / TRAIL Antibody - Immunohistochemistry of TRAIL in human brain tissue with TRAIL antibody at 20 µg/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $365.00
TNFSF10 / TRAIL Antibody
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TNFSF10 / TRAIL Antibody - Western blot of TRAIL antibody
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
TNFSF10 / TRAIL Antibody
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TNFSF10 / TRAIL Antibody - Western blot of TRAIL (S63) pAb in extracts from HUVEC cells.
Select
Rabbit Polyclonal to Human TNFSF10 / TRAIL
Human
IF, IHC, WB
Unconjugated
100µl   $345.00
TNFSF10 / TRAIL Antibody - Immunohistochemistry of TRAIL in human brain with TRAIL antibody at 20µg/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ICC, IHC, WB
Unconjugated
100µg   $435.00
TNFSF10 / TRAIL Antibody - Immunofluorescence staining of TNFSF10 in A549 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with mouse anti-human TNFSF10 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
Select
Mouse Monoclonal [clone 101] (IgG1) to Human TNFSF10 / TRAIL
Human
ICC, IF
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
TNFSF10 / TRAIL Antibody - Peptide - + Immunofluorescence analysis of A549 cells, using CD253 antibody.
Select
Rabbit Polyclonal (IgG) to Human TNFSF10 / TRAIL
Human
ELISA, IF, WB
Unconjugated
100µg   $305.00
Select
Rabbit Polyclonal to Human TNFSF10 / TRAIL
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
TNFSF10 / TRAIL Antibody - Anti-Murine TRAIL Western Blot Reduced
Select
Rabbit Polyclonal to Mouse TNFSF10 / TRAIL
Mouse, Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00

Viewing 1-25 of 151 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).