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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNFRSF21 / DR6

tumor necrosis factor receptor superfamily, member 21

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Gene Name: tumor necrosis factor receptor superfamily, member 21
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF21, CD358 antigen, BM-018, DR6, TNFR-related death receptor 6, CD358, Death receptor 6
Target Sequences: NM_014452 NP_055267.1 O75509

Filtered by: None
Target
TNFRSF21 / DR6 (77)
Reactivity
Human (67)
Mouse (16)
Rat (5)
Chimpanzee (3)
Gibbon (3)
Application
IHC (5)
IHC-P (2)
WB (54)
Flo (9)
ELISA (27)
ICC (6)
IP (7)
Host
rabbit (58)
mouse (18)
rat (1)
Isotype
IgG (35)
IgG1 (8)
IgG1,k (1)
IgG2a (1)
IgG2a,k (7)
Clonality
monoclonal mc (18)
polyclonal pc (59)
Clone
1B1 (1)
DR-6-04-EC (7)
Format
AP Conjugated (4)
APC (2)
APC Conjugated (5)
Azide-free (1)
Biotin Conjugated (7)
Concentrated (1)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (7)
PE Conjugated (8)
Unconjugated (34)
Epitope
aa356-385 (8)
aa406-605 (8)
aa420-568 (8)
aa42-335 (5)
aa38-87 (4)
aa371-655 (2)
aa372-665 (1)
aa42-56 (1)
pSer562 (1)
Publications
No (77)
Showing 1-25 of 77 results

IHC-plus™ TNFRSF21 / DR6 Antibody (aa356-385) LS-B10688
Rabbit Polyclonal to Human TNFRSF21 / DR6
Human
IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Anti-TNFRSF21 / DR6 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Anti-TNFRSF21 / DR6 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TNFRSF21 / DR6 Antibody LS-C125490
Rabbit Polyclonal (IgG) to Rat TNFRSF21 / DR6
Mouse, Rat, Human
WB
Unconjugated
100µg 0.5mg/ml  $495.00

TNFRSF21 / DR6 Antibody (aa42-335, clone DR-6-04-EC) LS-C44700
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, IP
Unconjugated
0.2mg  $415.00

TNFRSF21 / DR6 Antibody LS-C320
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
0.1mg  $365.00
Western blot of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.

TNFRSF21 / DR6 Antibody LS-C18660
Rat Monoclonal (IgG2a) to Human TNFRSF21 / DR6
Human
Flo
Unconjugated
100µg 1mg/ml  $395.00

TNFRSF21 / DR6 Antibody (aa406-605) LS-C296886
Rabbit Polyclonal to Mouse TNFRSF21 / DR6
Mouse, Rat
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $545.00
Western blot of recombinant TNFRSF21 / DR6.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TNFRSF21 / DR6 Antibody (aa372-665) LS-C14935
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ICC, WB
Unconjugated
100µg  $590.00

TNFRSF21 / DR6 Antibody (clone 1B1) LS-C139126
Mouse Monoclonal [clone 1B1] (IgG1,k) to Human TNFRSF21 / DR6
Human
ELISA
Unconjugated
100µg  $365.00
Detection limit for recombinant GST tagged TNFRSF21 is 0.1 ng/ml as a capture antibody.

TNFRSF21 / DR6 Antibody LS-C307941
Mouse Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
WB
Unconjugated
50µg  $560.00

TNFRSF21 / DR6 Antibody LS-C146897
Rabbit Polyclonal to Rat TNFRSF21 / DR6
Mouse, Rat, Human
WB
Unconjugated
30µg  $245.00; 100µg  $405.00

TNFRSF21 / DR6 Antibody (aa371-655) LS-C376901
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human pancreas using antibody at 1:100 dilution.
Western blot. All lanes: TNFRSF21 antibody at 4 ug/ml. Lane 1: K562 whole cell lysate. Lane 2: Jurkat whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 72 kDa. Observed band size: 72 kDa.

TNFRSF21 / DR6 Antibody (aa42-335) LS-C14936
Mouse Monoclonal (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
Unconjugated
100µg  $560.00

TNFRSF21 / DR6 Antibody (clone DR-6-04-EC) LS-C759218
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
Unconjugated
100µg 1mg/ml  $425.00
DR6 Antibody in Flow Cytometry (Flow)

TNFRSF21 / DR6 Antibody (aa42-335, clone DR-6-04-EC) LS-C46073
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
Unconjugated
0.1mg 1mg/ml  $290.00
Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody (DR-6-04-EC). Cell nuclei visualized by DAPI (blue).
Flow cytometry analysis of cell surface expression of DR6 in 6 different cell lines using purified anti-DR6 antibody (DR-6-04-EC) (detection by Goat anti-mouse IgG1 PE).

TNFRSF21 / DR6 Antibody (aa42-335, clone DR-6-04-EC, PE) LS-C46512
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
PE Conjugated
0.1mg 0.1mg/ml  $385.00

TNFRSF21 / DR6 Antibody (phospho-Ser562) LS-C800757
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

TNFRSF21 / DR6 Antibody (clone DR-6-04-EC, FITC) LS-C664248
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
FITC Conjugated
0.1mg 1mg/ml  $345.00

TNFRSF21 / DR6 Antibody LS-C349094
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cell lines.

TNFRSF21 / DR6 Antibody LS-C404905
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.6mg/ml  $205.00; 60µl 0.6mg/ml  $235.00; 120µl 0.6mg/ml  $295.00; 200µl 0.6mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human brain using TNFRSF21 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of paraffin-embedded Human brain using TNFRSF21 Polyclonal Antibody at dilution of 1:20.

TNFRSF21 / DR6 Antibody (aa42-335, clone DR-6-04-EC, Concentrated) LS-C202238
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, IP
Unconjugated, Concentrated
100µg  $485.00

TNFRSF21 / DR6 Antibody (aa356-385) LS-C325836
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
200µl  $590.00

TNFRSF21 / DR6 Antibody LS-C779079
Rabbit Polyclonal to Human TNFRSF21 / DR6
Mouse, Human
ELISA, WB
Unconjugated
100µg 100µl 1mg/ml  $305.00

TNFRSF21 / DR6 Antibody LS-C489542
Rabbit Polyclonal to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

TNFRSF21 / DR6 Antibody LS-C402242
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
20µl 0.4mg/ml  $205.00; 60µl 0.4mg/ml  $235.00; 120µl 0.4mg/ml  $295.00; 200µl 0.4mg/ml  $395.00
Western blot analysis of Human fetal brain tissue, using TNFRSF21 Polyclonal Antibody at dilution of 1:420.

TNFRSF21 / DR6 Antibody LS-C489544
Rabbit Polyclonal to Mouse TNFRSF21 / DR6
Mouse
ELISA
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00
Showing 1-25 of 77 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).