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TNFRSF19 / TROY

tumor necrosis factor receptor superfamily, member 19

TNFRSF19 / TROY is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene Name: tumor necrosis factor receptor superfamily, member 19
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF19, TAJ-alpha, TRADE, TROY, Toxicity and JNK inducer, TAJ
Target Sequences: NM_018647 NP_061117.2 Q9NS68

Publications (1)

1
Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response. Stepan Coufal, Natalie Galanova, Lukas Bajer, Zuzana Gajdarova, Dagmar Schierova, Zuzana Jiraskova Zakostelska, Klara Kostovcikova, Zuzana Jackova, Zuzana Stehlikova, Pavel Drastich, Helena Tlaskalova-Hogenova, Miloslav Kverka. Cells. 2019 Jul;8:719. [Full Text Article] [PubMed:31337064] [PMC:PMC6678638]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).