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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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TNFRSF18 / GITR
tumor necrosis factor receptor superfamily, member 18
TNFRSF18 / GITR is a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
| Gene Name: | tumor necrosis factor receptor superfamily, member 18 |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF18, AITR, CD357, CD357 antigen, GITR, GITR-D |
| Target Sequences: | NM_004195 NP_004186.1 Q9Y5U5 |
Publications (1)
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